The International Society for Gastrointestinal Hereditary Tumors (InSiGHT) is an international multidisciplinary,

scientific organization. Our mission is to improve the quality of care of patients and families with any hereditary

condition resulting in gastrointestinal tumors.

We do this by:

• Educating physicians and other healthcare professionals in the molecular genetics and clinical

management of gastrointestinal hereditary tumor syndromes

• Housing and curating the most comprehensive database of DNA variants t hat contribute to

gastrointestinal cancer

• Supported by a commit tee of world lead ing experts, systematically assigning pathogenicity to

variants in the genes predisposing to gastrointestinal cancer

• Encouraging research into all aspects of gastrointestinal hereditary tumor syndromes

• Providing a forum for t he presentation of data, d iscussion of controversial areas involved in t he care

of patients and their families, and facilitation of collaborative studies

• Assisting institutions and individuals interested in beginning or maintaining a r egistry for families with

gastrointestinal hereditary tumor syndromes




InSiGHT was formed in 2005 by the merger of the Leeds Castle Polyposis Group (LCPG) and the

International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). In 2010 it became an incorporated charity in England and Wales.

In 1985 a meeting of experts with an interest in polyposis syndromes was organized at Leeds Castle, an

historic castle in Kent, UK. In 1989 the LCPG was formally established.

The ICG-HNPCC was conceived in Jerusalem, Israel, in 1989. In 1 990 the first formal meeting of the ICGHNPCC was held in Amsterdam, The Netherlands.

In 1997 the first joint meeting of LCPG and ICG-HNPCC took place in Noordwijk, The Netherlands. At the

third joint meeting in Venice, Italy in 2001 it was agreed that the ICG-HNPCC should merge with the LCPG to form a new society – InSiGHT.